Energy requirement for degradation of tumor-associated protein p53.
نویسندگان
چکیده
منابع مشابه
Preliminary Evaluation for Vacuum Membrane Distillation (VMD) Energy Requirement
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The p53 tumor suppressor exerts anti-proliferative effects in response to various types of stress including DNA damage and abnormal proliferative signals. Tight regulation of p53 is essential for maintaining normal cell growth and this occurs primarily through posttranslational modifications of p53. Here, we describe Pirh2, a gene regulated by p53 that encodes a RING-H2 domain-containing protei...
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Mutations in the p53 tumor suppressor gene occur in about 50% of all human tumors, making it the most frequent target for genetic alterations in cancer (for recent reviews on p53 see Refs. 1–5). Such mutations probably facilitate carcinogenesis primarily through abrogating the tumor suppressor activities of the wild type p53 protein, although at least some forms of tumor-associated mutant p53 p...
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The tumor suppressor p53 is a multi-functional protein, its functions covering cell cycle control, apoptosis, senescence, genome integrity maintenance, metabolism, cellular reprogramming and autophagy. Regulation of p53 stability is a central process in controlling these p53 functions. Multiple E3 ligases that mediate p53 degradation through the ubiquitination proteasome pathway have been well ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1984
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.4.3.442